The ability to anticipate future events allows us to plan and exert control over our lives, but it may also contribute to stress-related increased risk for the diseases of aging, according to a study by UCSF researchers.
In a study of 50 women, about half of them caring for relatives with dementia, the psychologists found that those most threatened by the anticipation of stressful tasks in the laboratory and through public speaking and solving math problems, looked older at the cellular level. The researchers assessed cellular age by measuring telomeres, which are the protective caps on the ends of chromosomes. Short telomeres index older cellular age and are associated with increased risk for a host of chronic diseases of aging, including cancer, heart disease and stroke.
“We are getting closer to understanding how chronic stress translates into the present moment,” said Elissa Epel, PhD, an associate professor in the UCSF Department of Psychiatry and a lead investigator on the study. “As stress researchers, we try to examine the psychological process of how people respond to a stressful event and how that impacts their neurobiology and cellular health. And we’re making some strides in that.”
The researchers also found evidence that caregivers anticipated more threat than non-caregivers when told that they would be asked to perform the same public speaking and math tasks. This tendency to anticipate more threat put them at increased risk for short telomeres. Based on that, the researchers propose that higher levels of anticipated threat in daily life may promote cellular aging in chronically stressed individuals.
“How you respond to a brief stressful experience in the laboratory may reveal a lot about how you respond to stressful experiences in your daily life,” said Aoife O’Donovan, PhD, a Society in Science: Branco Weiss Fellow at UCSF and the study’s lead author. “Our findings are preliminary for now, but they suggest that the major forms of stress in your life may influence how your respond to more minor forms of stress, such as losing your keys, getting stuck in traffic or leading a meeting at work. Our goal is to gain better understanding of how psychological stress promotes biological aging so that we can design targeted interventions that reduce risk for disease in stressed individuals. We now have preliminary evidence that higher anticipatory threat perception may be one such mechanism.”
The study will be published in the May issue of the journal Brain, Behavior and Immunity.
Research on telomeres, and the enzyme that makes them, was pioneered by three Americans, including UCSF molecular biologist and co-author on this manuscript Elizabeth Blackburn, PhD, who co-discovered the telomerase enzyme in 1985. The scientists received the Nobel Prize in Physiology or Medicine in 2009 for this work.





Babies are not able to metabolize or excrete caffeine very well, so a breastfeeding mother’s consumption of caffeine may lead to caffeine accumulation and symptoms such as wakefulness and irritability, according to an interview with expert Ruth Lawrence, MD, published in
A study of mothers and their young babies has shown that mothers who suffer migraine headaches are more than twice as likely to have babies with colic than mothers without a history of migraine say neurologists at the University of California, San Francisco (UCSF).
“That’s not fair!” It’s a common playground complaint. But how early do children acquire this sense of fairness? Before they’re 2, says a new study. “We found that 19- and 21-month-old infants have a general expectation of fairness, and they can apply it appropriately to different situations,” says University of Illinois psychology graduate student Stephanie Sloane, who conducted the study with UI’s Renée Baillargeon and David Premack of the University of Pennsylvania. The findings appear in
Research designed to understand the effect of text messaging on language found that texting has a negative impact on people’s linguistic ability to interpret and accept words. The study, conducted by Joan Lee for her master’s thesis in linguistics, revealed that those who texted more were less accepting of new words. On the other hand, those who read more traditional print media such as books, magazines, and newspapers were more accepting of the same words.
When it comes to mental health information Wikipedia is a credible source according to a new study from the University of Melbourne. The often consulted, but sometimes doubted, website is the most highly rated source for accessing information on mental-health related topics.

Mice genetically engineered to be susceptible to autism-like behaviors that were exposed to a common flame retardant were less fertile and their offspring were smaller, less sociable and demonstrated marked deficits in learning and long-term memory when compared with the offspring of normal unexposed mice, a study by researchers at UC Davis has found. The researchers said the study is the first to link genetics and epigenetics with exposure to a flame retardant chemical.




Loading...







Recent comments